Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Twenty-one patients were given Pycnogenol at 150 mg daily and 18 patients received no treatment for a period of eight weeks. A good-quality study was conducted in 77 diabetic patients who received their standard antidiabetic treatment along with 100 mg Pycnogenol a day or placebo for 12 weeks. In this study, 155 peri-menopausal women were enrolled in a double-blind, placebo-controlled study. It comes from the bark of a European pine tree. Although these may still be high quality, the active compounds are more likely to vary. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. For children with ADHD, research suggests that symptoms start to return after about a month without taking maritime pine, so taking periodic breaks shouldnt make it any less effective. , Improves Symptoms Associated With Menopause, A number of women experience physical discomfort due to symptoms of menopause. Next, the doctors discuss the link between salt and hypertension, and Dr. Steve gives his insight on drinking red wine for a healthy heart. Pine bark extract has been studied with regard to its ability to help diabetic patients. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Helps maintain high vitamin C and E blood levels for their antioxidant effects. DOI: Chowdhury WK, et al. The results of a 2013 animal study suggest that pine bark extract may help to reduce damage to nerve cells following a traumatic brain injury. A 10 week clinical trial with 30 children shows that Pycnogenol may improve symptoms of Crohns disease. Typical doses range from 50 milligrams to 450 milligrams per day. In some people lung inflammation is caused by leukotrienes chemicals that are released by the body after a person encounters allergens. Various brands of pycnogenol are available. We all know the power of antioxidants to improve health and thehigh-antioxidant foodswe should eat regularly. There are also several other natural ADHD remedies you can try. Instead, use plain water to wipe yourself and then dry your bottom afterward. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. For most people, pine bark extract doesnt cause any side effects. A clinical trial of 57 ADHD children found that daily Pycnogenol (1 mg/kg) for one month may reduce hyperactivity symptoms. Grape seed extract may have heart-health benefits. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. Unlike drug manufacturers, the makers of supplements dont have to show their products are safe or effective before selling them on the market. Lowers Blood Pressure. Along with the rest of the crew, he developed symptoms of vitamin-C deficiency. Certain studies used combination products, so its unknown what the contribution of Pycnogenol itself was. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). Pine bark extract is usually taken by mouth in capsule form. A study of 32 people with heart failure lasting 12 weeks suggests that a combination of Pycnogenol with CoQ10 (PycnoQ10) may improve blood pressure, heart function, edema, and capacity for physical activity [40]. Beta 1-3D Glucan is recognized by cells in the immune system, and can modify your immune system responses. (3), Ototoxicity is ear poisoning and can occur when exposed to certain drugs or chemicals, such as cisplatin, that damage the inner ear or the vestibulocochlear nerve. The dosage in most clinical studies varied between 50-360 mg/day. Upset stomach. Pycnogenol (up to 200 mg/day) may improve asthma and reduce inflammatory asthma markers in the blood, leukotrienes, after 4 weeks, according to a randomized placebo-controlled trial of 26 asthma patients [14]. Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. Clearer skin, healthier hair there are a lot of claims about the health benefits of biotin. Pycnogenol is considered safe when taken orally in a dose of 50 to 450 mg per day for one year. Moreover, Pycnogenol group either reduced or discontinued the use of asthma drugs. Two studies illustrate the possibilities: One was a randomized, double-blind, placebo-controlled, crossover study in which 26 asthmatic patients were given either a maximum of 200 mg a day of Pycnogenol or placebo for the first period of four weeks and then crossed over to the alternate treatment for the next four weeks. Learn more about how to get even skin tone. are clickable links to medically peer-reviewed studies. You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. editor, The Gale Encyclopedia of Alternative Medicine, third edition, 2009. In a study of 72 children undergoing cancer chemotherapy, Pycnogenol reduced painful mouth ulcers, both alone and in combination with vitamin E [79]. For that reason, you should be careful taking pine bark if you have hypertension or diabetes. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. Diindolylmethane, or DIM for short, is a plant indolea plant compound with health-promoting properties. Here are the many health benefits believed to be possible with Pycnogenol: Reduces "leaky" blood vessels by making the wall proteins (collagen, elastin) more resistant to damage. Lower the risk of Alzheimer's disease. Chewing gum with Pycnogenol (2.5 mg/piece) for 4 weeks reduced bad breath and mouth bacteria in a trial of 22 people [57]. (13). Pycnogenol is similar to grape seed extract and cocoa polyphenols as those are the three most common . Ana received her MS in Pharmacy from the University of Belgrade. The extract has been widely studied for the past 40 . Subjects in the study that took Pycnogenol ended up taking fewer painkillers [51]. Helps Treat Erectile Dysfunction. Vertigo. Considering that about 1 of 3 adults in the U . Seems like it must be pretty amazing, but lets look closer. Moreover, Pycnogenol treatment reduced the use of painkillers. The outcome showed significant healing when compared to those subjects who were not given any drug or remedy, concluding that Pycnogenol may be an effective remedy for healing of surgery-related lesions. Eighty-six patients were treated either with Pycnogenol at 150 mg or 300 mg daily or the drugs diosmin and hesperidin (Daflon)at 1,000 mg daily for two months. Circulation and Jet Lag on Long Flights. Note that each number in parentheses [1, 2, 3, etc.] So begins my look at the natural supplement, pycnogenol (French Maritime Pine Bark Extract)benefits. Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . While these results are promising, there isnt enough research to fully understand the effect of antioxidant levels on ADHD symptoms. Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women [Abstract]. . 2005 - 2023 WebMD LLC. If you choose to use Pycnogenol, follow the dosage instructions on the label. (1, 2). It does this by improving the time it takes the body to reach a fatigued state through increased serum NAD+ levels. whole-body health. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Pycnogenol has several benefits to your health and beauty. Since components of Pycnogenol can be modified during digestion and absorption as well as by the liver, diseases that affect the gut or liver may increase or decrease its effects [84]. Chemistry. In another study, 45 men with ED were given 1.7 grams of L-arginine a day during the first month, 40 mg Pycnogenol twice daily during the second month, and the dose increased to three 40-mg Pycnogenol doses daily during the third month. Still, more research is needed to better understand these findings and pine bark extracts role in reducing damage from head trauma. Taking pine bark extract supports healthy blood pressure. PQQ (pyrroloquinoline quinone), also called methoxatin, is a vitamin-like compound that exists naturally in soil and a variety of foods, including spinach, kiwi, soybeans, and human breastmilk . Pycnogenol seems well-tolerated for use in adults for up to 6 months. Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. Research indicates that Pycnogenol provides an increase in endurance performance of trained athletes. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. ", Journal of Medicinal Food: "Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark, Pycnogenol. Used early on, it may prevent eye damage and blindness from diabetes [34]. Here are the many health benefits believed to be possible with Pycnogenol: Now lets dive into the first condition it could help treat. A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. ", Natural Medicines Comprehensive Database web site: "Pycnogenol.". Posted on Thursday, August 14, 2014 The majority of this article is information obtained from the book "All About DIM" by Michael A. Zeligs, MD and A. Scott Connelly, MD. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. Can Pycnogenol help? In the study, women taking Pycnogenol were more satisfied and compliant to the regimen [24]. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. In clinical research, doses up to about 300 mg/day have been used for up to one year without major safety concerns [33, 37]. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. Pycnogenol health benefits. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. The combination of L-arginine and Pycnogenol may help in erectile dysfunction by boosting nitric oxide, which potentially could improve blood flow in men [66]. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. Remember to speak with a doctor before taking Pycnogenol. Also, its important to note that some of these studies were funded by Horphag Research, the original developers and exclusive marketers of Pycnogenol. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Researchers suggest that it may have stronger benefits than elastic compression stockings. In a good-quality study, 24 adults aged 24 to 53 years old with attention deficit hyperactivity disorder (ADHD) were given Pycnogenol, placebo, or the standard drug for three weeks. 7. By clicking Subscribe, I agree to the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Becoming a Vegetarian: Foods to Choose From. The researchers of the study propose that pycnogenol may reduce pain and cramps during retraining and rehabilitation in people with blood vessel problems [11]. Consequently, blood pressure is lowered. Possess Anti-Inflammatory Action. In 19 smokers, increased platelet aggregation was more significantly reduced by 200 mg than either 10 mg or 100 mg of Pycnogenol. Cigarette smoking increases platelet aggregation. The following purported benefits of Pycnogenol are only supported by limited, low-quality clinical studies. Some people who have asthma have higher levels of leukotrienes in their blood. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? After taking a break for one to two weeks, they can start taking it again for several weeks. The list goes on a bit further, as the OPCs in thisextract may inhibit lipid peroxidation, platelet aggregation, capillary permeability and fragility, and to affect enzyme systems, which basically means it may be a natural treatment for many serious health conditions, such as stroke and heart disease. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Masquelier was easily able to create a pine bark extract from materials that were otherwise known as waste. In addition to general healthy eating, some specific vitamins and minerals may help improve ADHD. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. So it . painful urination. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. Can you get pycnogenol naturally from foods? The study provided clear evidence that Pycnogenol does, indeed, offer photoprotection however, it came out even better than expected, showing that it may be used to reduce hyperpigmentation of human skin while improving the skin barrier function and extracellular matrix homeostasis. (6). Two doses of 100 mg of Pycnogenol were taken two to three hours before flights and two additional capsules taken six hours later then one capsule the next day. A 2006 study found that children who took a daily pine bark extract supplement for four weeks had significantly lower levels of hyperactivity. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). Rare cases of liver disease. 3. In a smaller study of 58 people, pycnogenol reduced the inflammatory marker CRP [49, 50]. The standard dose appears to be 100-200 mg/day. Researchers suggest that it may have stronger benefits than elastic compression stockings. According to a large analysis, Pycnogenol may reduce osteoarthritis symptoms and pain short-term [45, 46]. Start with a low dose so you can be sure it doesnt cause any side effects. There are several causes for erectile dysfunction, such as neurological and psychological issues. Pycnogenol may stimulate the immune system. Video: Why You Need Zinc and Where to Find It. Interactions. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. Thirty patients with diabetic ulcers were treated with 150 mg Pycnogenol daily for four weeks and another group of 30 comparable patients received no treatment. Based on another study of 6 trained and 7 untrained people, an antioxidant combination product containing Pycnogenol (Lactaway) may increase endurance. Organika Pycnogenol 50mg 50 Tablets . Boost gastrointestinal health. Its used as a natural supplement for several conditions, including dry skin and ADHD. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Another study found this supplement can even halt progression of vision . What Are These Tiny Red Spots on My Skin (Petechiae)? A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. This ensures that there is a healthy flow of blood to and from the heart. Rating: 100%. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. Your email address will not be published. Systolic blood pressure measures how much blood is pumping from your heart to your arteries. It is found primarily in southwestern France and is used to help people with asthma, allergies, hay fever, and other health conditions.. Work with your pediatrician to see if there are contraindications for each child. This study adds to a body of research showing the benefits of Pycnogenol . Another 2006 study examined the effects of the antioxidant activity of pine bark extract on oxidative stress, which is thought to be one of the nongenetic factors contributing to ADHD. A clinical trial of 60 health professionals found that Pycnogenol (150 mg/day) may improve cognitive function, attention, mental performance and specific professional skills after 12 weeks. The U.S. Food and Drug Administration (FDA) does regulate dietary supplements; however, it treats them like foods rather than medications. It should never be used as a replacement for approved medical therapies. Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. A small 2017 study examined the effects of pine bark extract in treating cardiovascular risk factors associated with menopause. Pycnogenol seems well-tolerated for use in adults for up to 6 months. It had the best results when combined with compression stockings, but worked just as well alone [28]. In the Pycnogenol-treated group, blood sugar levels were significantly lowered as compared to those not on Pycnogenol. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. But what makes this miracle ingredient so amazing? A 2004 animal study also found that applying a gel containing pine bark extract sped up the wound-healing process. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. The specific tree from which the bark is extracted is called a maritime pine. More specifically, because it strengthens the capillaries in the retina, Mirtogenol can help prevent retinopathy. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. As a skin powder, however, you can use it safely for up to six weeks. We do not aim to diagnose, treat, cure or prevent any illness or disease. Another clinical trial of 76 people with allergic asthma also suggests that Pycnogenol may reduce IgE antibodies and asthma symptoms [18, 16]. However, it's always a good idea to start with a low dose so you can monitor how your body responds. During week, five without, treatment, reduction of cramps was maintained in all three groups. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. It may cause side effects such as: Dizziness. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. Furthermore, when CHS was suppressed by 71% with exogenous treatment with cis-urocanic acid, the putative epidermal mediator of photoimmunosuppression, 0.2% Pycnogenol lotion reduced the immunosuppression to 18%. Prunes and prune juice have many health benefits. 2005 - 2023 WebMD LLC. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. This review noted that pine bark extract may also help with: In addition to its skin-healing properties, pine bark extract also shows promise for helping children manage ADHD symptoms. Regardless of what youre using it for, its best to start with the lowest possible dose. This article explains which supplements are believed to be safe during pregnancy and which ones you should avoid. The study suggests it may increase desire, arousal, lubrication, orgasm, satisfaction and reduce pain [70]. During the first month on L-arginine, only five percent of patients experienced normal erection. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. One study found that Pycnogenol may reduce the activity of the inflammatory enzymes COX1 and COX2, similar to how NSAID drugs work. Mental function. Erythritol: Is This Healthy Sweetener the Real Deal? 7. Its likely that muscle recovery time improved as well due to the high antioxidants pine bark extract contains. Its quality is specified in the United States Pharmacopeia [3]. Quality and active ingredients in supplements may vary widely from maker to maker. Learn about all the potential benefits of Pycnogenol and find out which ones are most supported by science. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Prenatal nutrition can be confusing. Some health benefits of Pycnogenol include:. Pycnogenol led to a reduction of muscle cramps from 4.8 a week to 1.3 at week four. A number of clinical trials suggest that Pycnogenol may lower blood glucose if taken daily for at least 12 weeks. Score one for diabetes control and fewer risk factors for the heart. 4 Items . Proper nutrition is essential for ADHD treatment. In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. In contrast, bleeding still occurred in the control group [61]. The researchers concluded that pine bark extract may increase production of hyaluronic acid and collagen, which are both found in many popular antiaging products. Known for its antioxidant properties, Pycnogenol offers a wide range of potential health benefits. It has been studied for its effects on everything from mental function to treating high blood pressure. Memorial Sloan-Kettering Cancer Center web site: "About Herbs: Pine Bark Extract. In a study of 61 ADHD children, pycnogenol reduced hyperactivity, improved attention, and motorics after 1 month. Additionally, the results showed that the extract has significant anti-pseudomonas activity, making it a potential natural remedy and possible preventive measure for infections. Pycnogenol is not approved by the FDA for medical use. Studies have been conducted to review the effects of pine bark extract on pseudomonas infectious wounds. Pycnogenol in metabolic syndrome and related disorders [Abstract]. Some small studies suggest it may also protect against coronary artery disease and blood clots. from the bark of the French maritime pine tree. Ask your doctor for advice. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. (2015). There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). Studies have found that when taken along with an inhaler, Pycnogenol can reduce leukotrienes, helping to relieve lung inflammation and limit frequency of inhaler use., Many people develop osteoarthritis as they age. In a clinical trial of 40 men with erectile dysfunction, 92.5% of the men on this combination regained normal erections after 3 months. It can also stabilize mast cells, which release histamine and trigger allergic reactions. A high number signals high blood pressure. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. Forty patients were treated with either 600 mg chestnut seed extract a day or 360 mg Pycnogenol a day over a period of four weeks. Pycnogenol reduced foot swelling in 79% of the patients, versus one percent in the placebo group. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. The study showed that many people who participated had a drop in their systolic blood pressure after taking Pycnogenol. (5). Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. Joe Cohen flipped the script on conventional and alternative medicine and it worked. Pycnogenol treatment resulted in more normal-looking sperm. Information is shared for educational purposes only. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. If youre native to Oregon, you likely know all about marionberries. Studies have found that nattokinase thins the blood and dissolves accumulated solids in it. Some people seek to manage ADHD symptoms through an ADHD diet. Optimal doses of pycnogenol have not been set for any condition. Pycnogenol-treated patients had significant improvement in symptoms as well as a reduction in leg swelling as compared to those not receiving treatment. ( 4) Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. Make sure to seek out the advice of your physician prior to using pine bark extract or the branded name, Pycnogenol.

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